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4-Hydroxyacetophenone (also known as p-Hydroxyacetophenone, CAS No.: 99-93-4) is a widely used fine chemical with stable performance, high purity, and broad compatibility across cosmetics, pharmaceuticals, fragrances, and polymer materials. In this blog post, SACH, as high purity active raw materials manufacturing factory, will share the properties of antioxidant 4-Hydroxyacetophenone for sale, its advantages, applications, etc.
Properties of 4-Hydroxyacetophenone and Its Structural Features
4-Hydroxyacetophenone (CAS No.: 99-93-4) is characterized by a phenolic hydroxyl group positioned para to the acetyl group, giving it balanced reactivity and stability. This structure contributes to its antioxidant capacity, biological compatibility, and ability to participate in multiple synthetic pathways.
Key physical and chemical properties include:
* Appearance: White crystal or crystalline powder
* Density: 1.109 g/cm³ (25°C)
* Flash point: 121 °C
* Boiling point: 147–148 °C
* Solubility: Easily soluble in ethanol and ether
* Odor: Mild, non-irritating
These characteristics allow the ingredient to be incorporated in both aqueous and solvent-based systems, supporting consistent behavior in cosmetic emulsions, pharmaceutical intermediates, and fragrance formulations.
4-Hydroxyacetophenone in Cosmetic Formulations
In the past decade, 4-Hydroxyacetophenone in cosmetics has gained significant attention due to its multifunctional role as a preservative booster, antioxidant, and stabilizing agent. It is widely used in skin-care products such as creams, lotions, toners, facial serums, and sensitive-skin formulations.
Why cosmetics manufacturers prefer 4-Hydroxyacetophenone
1. Mild preservative boosting effect
It synergizes with common preservatives, reducing irritation levels while maintaining antimicrobial efficiency.
2. Strong antioxidant capability
By slowing the oxidative degradation of oils, active ingredients, and emulsions, it prolongs shelf life and improves overall formulation stability.
3. Compliance with global cosmetic regulations
It meets EU cosmetic ingredient regulations, China' s IECIC standards, and global safety norms, making it suitable for international brands.
4. Stability in modern clean-beauty formulas
As demand rises for low-irritation, low-sensitization ingredients, 4-Hydroxyacetophenone fits well within minimalist, fragrance-free, and sensitive-skin product lines.
Because of its versatility and safety record, it has become a preferred ingredient among formulators seeking effective preservation without compromising skin-feel.
Role of p-Hydroxyacetophenone in Pharmaceutical Intermediate Synthesis
The importance of p-Hydroxyacetophenone in pharmaceuticals lies in its role as a precursor for several high-value APIs (Active Pharmaceutical Ingredients). Its balanced reactivity allows it to participate in electrophilic substitution, esterification, condensation, and reduction reactions.
Main pharmaceutical applications include:
* Intermediate for paracetamol (acetaminophen) synthesis
It contributes to one of the world' s most widely used analgesic and antipyretic drugs.
* Raw material for cardiovascular drug development
Certain synthetic pathways rely on its structure as a starting point.
* Component for antipyretic and analgesic medicines
Its phenolic and ketone functionalities make it ideal for downstream chemical transformations.
* Key building block for new APIs and fine-chemical compounds
Research and manufacturing in chemical medicine benefit from its stability and consistent purity.
Because pharmaceutical production requires high reliability, our supply ensures HPLC ≥99% purity, low impurities, and consistent batch-to-batch performance.
Use of 4-Hydroxyacetophenone in Fragrances and Flavor Compounds
In the fragrance and flavor industry, 4-Hydroxyacetophenone serves as a valuable synthetic intermediate due to its ability to produce stable aromatic compounds.
Its primary applications include:
* Synthesis of floral fragrances
Used as a precursor for creating gardenia, hawthorn, and fresh floral notes.
* Component for edible flavors and daily-use fragrances
Its mild odor profile makes it suitable for blending in foods, beverages, and household fragrances.
* Intermediate for aroma-related resins and specialty materials
It provides structural stability during fragrance development.
The compound' s stability and predictable reactivity ensure high fragrance-yield efficiency during synthesis.
4-Hydroxyacetophenone in Polymer and Specialty Material Production
Beyond cosmetics and pharmaceuticals, 4-Hydroxyacetophenone in polymers is gaining traction as a raw material for specialty resins and light-stabilizing additives.
Typical uses include:
* Synthesis of antioxidants
Its phenolic group contributes to radical-scavenging performance in polymer matrices.
* Formulation of UV light stabilizers
Helps enhance durability in plastic materials exposed to sunlight.
* Production of modified resins and fine chemicals
Ensures improved mechanical and thermal properties in certain engineered plastics.
These applications demand high-purity, consistent materials—advantages that 4-Hydroxyacetophenone offers due to its well-controlled production standards.
Technical Advantages of High-Purity 4-Hydroxyacetophenone
Manufacturers often choose high-grade 4-Hydroxyacetophenone because its purity directly affects downstream product quality.
Key advantages include:
1. High Purity (≥99.0% by HPLC)
Low impurities support stable reactivity in pharmaceutical synthesis, cosmetic consistency, and fragrance precision.
2. Excellent Quality Stability
Strict quality management ensures uniformity across batches, meeting requirements for regulated industries such as cosmetics and medicine.
3. Broad Application Versatility
It is suitable for cosmetics, APIs, flavor and fragrance synthesis, and polymer modifications—providing ample flexibility for industrial users.
4. International Regulatory Compliance
Meets RoHS, REACH, and global cosmetic standards, allowing manufacturers to avoid import and certification issues.
5. Stable Supply Chain and Inventory
Large-scale production ensures sufficient stock, fast delivery, and reliable long-term supply, supporting continuous manufacturing needs.
Conclusion
4-Hydroxyacetophenone (p-Hydroxyacetophenone, CAS No.: 99-93-4) plays an increasingly important role across modern industries thanks to its high purity, mild sensory profile, structural versatility, and strong regulatory compliance. From cosmetic formulations and fragrances to drug intermediates and polymer materials, its stability and reactivity allow it to serve as a multifunctional and indispensable chemical raw material.
With reliable quality control, a high purity of ≥99%, and stable supply, it remains a preferred choice for manufacturers seeking consistency, safety, and performance in their production processes.
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